Selected publications from the Baumeister lab:

Targeting the paralog protein for degradation accounts for the opposite roles of NRBP1 and NRBP2 in regulating LINE1 retrotransposition

Wei Yang, Shaobo Cong, Jennifer Schwarz, Thilo Schulze, Sara Ullrich, Kristina Falkenstein, Denis Ott, Pia Eixmann, Angelica Trentino, Antje Thien, Thierry Heidmann, Ekkehard Schulze, Bettina Warscheid, Ralf Baumeister, Wenjing Qi (BioRxiv, Posted June 15, 2024).

SGK-1 mediated inhibition of iron import is a determinant of lifespan in C. elegans.
Gang Wu, Ralf Baumeister, and Thomas Heimbucher (2023)

Reprogramming of the transcriptome after heat stress mediates heat hormesis in Caenorhabditis elegans.  
Xu, F, Li, R., von Gromoff, E. D., Drepper, F., Knapp, B., Warscheid, B., Baumeister, R., Qi, W. (2023)

Molecular Mechanisms of Lipid-Based Metabolic Adaptation Strategies in Response to Cold.
Wu, Gang., Baumeister, R. and Heimbucher, T. (2023)

The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans.

Qi, W., Donner von Gromoff, E., Xu, F., Zhao, Q., Yang, W., Pfeifer, D., Maier, W., Long, L., Baumeister, R. (2021)

Metabolic adaptation to hypoxia: do worms and cancer cells share common metabolic responses to hypoxic stress

Baumeister, R., Murphy, C.T., Heimbucher, T. (2021)

TORC2-SGK-1 signaling integrates external signals to regulate autophagic turnover of mitochondria via mtROS

Heimbucher, T., Qi, W., Baumeister, R. Autophagy. 2020

Mitochondrial Perturbations Couple mTORC2 to Autophagy in C.elegans

Aspernig, H., Heimbucher, T., Qi W., Gangurde D., Curic S., Yan Y., Donner von Gromoff E., Baumeister R., Thien A.

Cell Rep, accepted November 2019

Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling

Kvainickas A., Nägele H., Qi W., Dokládal L., Jimenez-Organz A., Stehl L., Gangurde D., Zhao Q., Hu Z., Dengjel J., De Virgilio C., Baumeister R., Steinberg F.

LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena

Jiang YY., Maier W., Baumeister R., Minevich G., Joachimmiak E., Wloga Dr., Ruan Z., Kannan N., Bocarro S., Bahraini A., VasudeaBahraini A., Vasudevan KK., Lechtreck K., Orias E., Gaertig J.

PLoS Genet., accepted July 24, 2019

Polo-like kinase 1 inhibits mTOR complex 1 and promotes autophagy

Ruf, S.*, Gelino, S., Langelaar-Makkinje, M., Wilkinson, D., Heberle, A.M., Gerberth, C. , Schwarz, J.J., Holzwarth, B., Warscheid, B., Meisinger, C., van Vugt, M.A.T.M., Baumeister*, R., Hansen, M., Thedieck*, K
Autophagy, accepted, July 18, 2016

Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. 
Eisenhardt, A.E., Sprenger, A., Röring, M., Herr, R., Weinberg, F., Köhler, M., Braun, S., Orth, J., Diedrich, B., Lanner, U.,Tscherwinski, N., Schuster,S., Dumaz, N., Schmidt, E., Baumeister, R., Schlosser, A., Dengjel, J., Brummer, T.
Oncotarget. 2016 Mar 28

TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition.
Thien A, Prentzell MT, Holzwarth B, Kläsener K, Kuper I, Boehlke C, Sonntag AG, Ruf S, Maerz L, Nitschke R, Grellscheid SN, Reth M, Walz G, Baumeister R, Neumann-Haefelin E, Thedieck K
Dev Cell. 2015 Mar 9;32(5):617-30.
PMID: 25727005

Prohibitin-Mediated Lifespan and Mitochondrial Stress Implicate SGK-1, Insulin/IGF and mTORC2 in C. elegans.
Gatsi R , Schulze B, Rodríguez-Palero MJ, Hernando-Rodríguez B, Baumeister R, Artal-Sanz M.
PLoS One. 2014 Sep 29;9(9):e107671.

Targeted Purification of SnAvi-Tagged Proteins.
Schäffer U, Baumeister R, Schulze E.
Methods Mol Biol. 2014;1177:163-74
PMID: 24943322  

Expression pattern and first functional characterization of riok-1 in Caenorhabditis elegans
Weinberg, F., Schulze, E., Fatouros, P., Schmidt, E., Baumeister, R.* and Brummer, T. *
* corresponding authors
Gene Exp Pattern (2014) Jun 12;15(2):124-134.

Doxycyclin ameliorates a starvation-induced germline tumor in C. elegans daf-18/PTEN mutants.
Tim Wolf, Wenjing Qi, Verena Schindler, Eva Diana Runkel, Ralf Baumeister
Exp Gerontol. 2014 Apr 15;
PMID: 24746511 

Mitochondrial stress: Balancing friend and foe. [Review]
Runkel, ED., Baumeister, R., and Schulze, E
Exp Gerontol. 2014 Mar 3.
PMID: 24603155 

pdr-1/hParkin negatively regulates the phagocytosis of apoptotic cell corpses in C. elegans. Cabello, J., Sämann, J., Gómez-Orte, E., Erazo, T., Coppa, A., Pujol, A., Büssing, I, Schulze, B, Lizcano, J.M., Ferrer*, I., Baumeister*, R., Dalfo, E. (* cocorresponding authors)
Cell Death Dis. 2014 Mar 13;5:e1120.
PMID: 24625979

Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells.
Kathrin Thedieck, Birgit Holzwarth, Mirja Tamara Prentzell, Christopher Boehlke, Kathrin Kläsener, Stefanie Ruf, Annika Sonntag, Lars Maerz, Sushma-Nagaraja Grellscheid, Elisabeth Kremmer, Roland Nitschke, E. Wolfgang Kuehn, Johan W. Jonker, Albert K. Groen, Michael Reth, Michael N. Hall, Ralf Baumeister
Cell – 15 August 2013 (Vol. 154, Issue 4, pp. 859-874)
PMID: 23953116

Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response.
Runkel, E., Liu, S., Baumeister, R.*, and Schulze E.
PLoS Genet 2013 9(3): e1003346.
*corresponding author
PMID: 23516373

AnchorCell-Nonautonomous Signaling of FOXO/DAF-16 to the Stem Cells of Caenorhabditis elegans. 
Qi W, Huang X, Neumann-Haefelin E, Schulze E, Baumeister R
PLoS Genet. Epub Aug 16. 2012;8(8):e1002836
PMID: 22916022 PMCID: PMC3420913

AnchorInhibition of Tau aggregation in a novel C. elegans model of Tauopathy mitigates proteotoxicity. 
Fatouros C, Pir GJ, Biernat J, Koushika SP, Mandelkow E, Mandelkow EM, Schmidt E, Baumeister R
Hum Mol Genet. 2012 Aug 15;21(16):3587-603
PMID: 22611162

A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation.
Dalle Pezze P, Sonntag AG, Thien A, Prentzell MT, Gödel M, Fischer S, Neumann-Haefelin E, Huber TB, Baumeister R, Shanley DP, Thedieck K
Sci Signal. 2012 Mar 27;5(217):ra25. (featured article).
DOI: 10.1126/scisignal.2002469
PMID: 22457331

A modelling-experimental approach reveals IRS dependent regulation of AMPK by Insulin.
Sonntag AG, Dalle Pezze P, Shanley DP, Thedieck K
FEBS J. 2012 Mar 27; (Systems Biology special issue).
DOI: 10.1111/j.1742-4658.2012.08582.x
PMID: 22452783

Temperature- and touch-sensitive neurons couple CNG and TRPV channel activities to control heat avoidance in Caenorhabditis elegans. 
Liu S, Schulze E, Baumeister R
PLoS One. 2012;7(3):e32360
PMID: 22448218

Novel roles of C. elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.
Studencka M, Konzer A, Moneron G, Wenzel D, Opitz L, Salinas-Riester G, Bedet C, Krüger M, Hell SW, Wisniewski JR, Schmidt H, Palladino F, Schulze E, Jedrusik-Bode M
Mol Cell Biol. 2011 Nov 14;
PMID: 22083954

Functional and Spatial Analysis of C. elegans SYG-1 and SYG-2, Orthologs of the Neph/Nephrin Cell Adhesion Module Directing Selective Synaptogenesis.
Wanner N, Noutsou F, Baumeister R, Walz G, Huber TB, Neumann-Haefelin E
PLoS One. 2011;6(8):e23598
PMID: 21858180

Perception of UV-B by the Arabidopsis UVR8 protein.
Rizzini L, Favory JJ, Cloix C, Faggionato D, O’Hara A, Kaiserli E, Baumeister R, Schäfer E, Nagy F, Jenkins GI, Ulm R.
Science. 2011 Apr 1;332(6025):103-6.
PMID: 21454788

Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis.
Lankisch TO, Metzger J, Negm AA, Voβkuhl K, Schiffer E, Siwy J, Weismüller TJ, Schneider AS, Thedieck K, Baumeister R, Zürbig P, Weissinger EM, Manns MP, Mischak H, Wedemeyer J
Hepatology. 2010 Dec 7
PMID: 21204070

The RET51/FKBP52 complex and its involvement in Parkinson disease.
Fusco D, Vargiolu M, Vidone M, Mariani E, Pennisi LF, Bonora E, Capellari S, Dirnberger D, Baumeister R, Martinelli P, Romeo G
Hum Mol Genet. 2010 May 4
PMID: 20442138

A Model organism approach: Defining the role of Neph proteins as regulators of neuron and kidney morphogenesis.
Neumann-Haefelin E, Kramer-Zucker A, Slanchev K, Hartleben B, Noutsou F, Martin K, Wanner N, Ritter A, Gödel M, Pagel P, Fu X, Müller A, Baumeister R, Walz G, Huber TB
Hum. Mol. Genet. 2010 19: 2347-2359
PMID: 20233749

SnAvi – a new tandem tag for high-affinity protein-complex purification. 
Schäffer U, Schlosser A, Müller KM, Schäfer A, Katava N, Baumeister R, Schulze E.
Nucleic Acids Res. 2010 Jan 4.
PMID: 20047968

The tyrosine kinase receptor RET interacts in vivo with AIP to alter survivin availability.
Vargiolu M, Fusco D, Kurelac I, Dirnberger D, Baumeister R, Morra I, Melcarne A, Rimondini R, Romeo G, Bonora E
J Clin Endocrinol Metab. 2009 Apr 14
PMID: 19366855

Caenorhabditis elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth.
Sämann J, Hegermann J, Gromoff EV, Eimer S, Baumeister R, Schmidt E
J Biol Chem. 2009 Feb 27
PMID: 19251702

Using Lateral Coupled Snakes for Modeling the Contours of Worms
Wang Q, Ronneberger O, Schulze E, Baumeister R, Burkhardt H
Pattern Recognition (2009): pp 542-551 (Chapter 54)
DOI: 10.1007/978-3-642-03798-6_55

SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.
Neumann-Haefelin E, Qi W, Finkbeiner E, Walz G, Baumeister R, Hertweck M
Genes Dev. 2008 Oct 1;22(19):2721-35
PMID: 18832074

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans
Tullet JMA, Hertweck MT, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, and Blackwell TK
Cell, Vol 132, 1025-1038, 21 March 2008
PMID: 18358814

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.
Schöbel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E, Seed B, Baumeister R, Haass C, Lichtenthaler SF
J Biol Chem. 2008 Mar 19
PMID: 18353773

An optimized split-ubiquitin cDNA-library screening system to identify novel interactors of the human Frizzled1 receptor.
Dirnberger D, Messerschmid M, Baumeister R
Nucleic Acids Res. 2008 Mar 4
PMID: 18319286

A mutation in CHN-1/CHIP suppresses muscle degeneration in Caenorhabditis elegans.
Nyamsuren O, Faggionato D, Loch W, Schulze E, Baumeister R
Dev Biol. 2007 Dec 1;312(1):193-202
PMID: 17961535

Caenorhabditis elegans as a model system for Parkinson’s disease.
Schmidt E, Seifert M, Baumeister R
Neurodegener Dis. 2007;4(2-3):199-217
PMID: 17596715

Presenilin function in Caenorhabditis elegans.
Smialowska A, Baumeister R
Neurodegener Dis. 2006;3(4-5):227-32
PMID: 17047361

Endocrine signaling in Caenorhabditis elegans controls stress response and longevity.
Baumeister R, Schaffitzel E, Hertweck M
J Endocrinol. 2006 Aug;190(2):191-202
PMID: 16899554

The genetics of synapse formation and function in Caenorhabditis elegans.
Seifert M, Schmidt E, Baumeister R
Cell Tissue Res. 2006 Nov;326(2):273-85
PMID: 16896949

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.
Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H
J Neurosci. 2006 Apr 5;26(14):3821-8
PMID: 16597736

Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress.
Springer W, Hoppe T, Schmidt E, Baumeister R
Hum Mol Genet. 2005 Nov 15;14(22):3407-23
PMID: 16204351

Caenorhabditis elegans neprilysin NEP-1: an effector of locomotion and pharyngeal pumping.
Spanier B, Stürzenbaum SR, Holden-Dye LM, Baumeister R
J Mol Biol. 2005 Sep 16;352(2):429-37
PMID: 16081104

ceh-16/engrailed patterns the embryonic epidermis of Caenorhabditis elegans.
Cassata G, Shemer G, Morandi P, Donhauser R, Podbilewicz B, Baumeister R
Development. 2005 Feb;132(4):739-49
PMID: 15659483

Automated assays to study longevity in C. elegans.
Hertweck M, Baumeister R
Mech Ageing Dev. 2005 Jan;126(1):139-45
PMID: 15610772

A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans.
Croce A, Cassata G, Disanza A, Gagliani MC, Tacchetti C, Malabarba MG, Carlier MF, Scita G, Baumeister R, Di Fiore PP
Nat Cell Biol. 2004 Dec;6(12):1173-9
PMID: 15558032

C. elegans metallothioneins: new insights into the phenotypic effects of cadmium toxicosis.
Swain SC, Keusekotten K, Baumeister R, Stürzenbaum SR
J Mol Biol. 2004 Aug 20;341(4):951-59
PMID: 15328611

Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans.
Hoppe T, Cassata G, Barral JM, Springer W, Hutagalung AH, Epstein HF, Baumeister R
Cell. 2004 Aug 6;118(3):337-49
PMID: 15294159

Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans.
Meissner B, Boll M, Daniel H, Baumeister R
J Biol Chem. 2004 Aug 27;279(35):36739-45
PMID: 15155758

Caenorhabditis elegans MPP+ model of Parkinson’s disease for high-throughput drug screenings.
Braungart E, Gerlach M, Riederer P, Baumeister R, Hoener MC
Neurodegener Dis. 2004;1(4-5):175-83
PMID: 16908987

Genes, longevity, and technology: meeting report from the 2nd conference on functional genomics of aging in Crete.
Baumeister R, Hertweck M
Sci Aging Knowledge Environ. 2004 Oct 6;2004(40):pe37
PMID: 15470191

C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span.
Hertweck M, Göbel C, Baumeister R
Dev Cell. 2004 Apr;6(4):577-88
PMID: 15068796

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